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Treatment with Mesenchymal Stromal Cells Overexpressing Fas-Ligand Ameliorates Acute Graft-versus-Host Disease in Mice. | LitMetric

AI Article Synopsis

  • * GvHD occurs when transplanted T cells attack the recipient’s cells, leading to high mortality rates, and currently, there is no effective treatment for this condition.
  • * Research has shown that mesenchymal stromal cells (MSC) could potentially treat GvHD, especially when enhanced by adenoviral overexpression of FasL, which delayed the onset of the disease and improved survival rates in a mouse model of acute GvHD.

Article Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) has the potential to cure malignant and non-malignant hematological disorders, but because of the serious side effects of this intervention its applications are limited to a restricted number of diseases. Graft-versus-host disease (GvHD) is the most frequent complication and the leading cause of mortality and morbidity following allo-HCT. It results from the attack of the transplanted T cells from the graft against the cells of the recipient. There is no clear treatment for this severe complication. Due to their immunomodulatory properties, mesenchymal stromal cells (MSC) have been proposed to treat GvHD, but the results did not meet expectations. We have previously showed that the immunomodulatory effect of the MSC was significantly enhanced through adenoviral-mediated overexpression of FasL. In this study, we have tested the properties of FasL-overexpressing MSC in vivo, in a mouse model for acute GvHD. We found that treatment with FasL-overexpressing MSC delayed the onset of the disease and increased survival of the mice.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745472PMC
http://dx.doi.org/10.3390/ijms23010534DOI Listing

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