Purpose: This study examined the effect of providing knowledge of results (KR) with, and without, promotion- and change-oriented feedback on repeated-sprint ability in swimmers.
Methods: Twenty-nine male and female swimmers (age = 16 [1] y, height = 1.74 [0.07] m, body mass = 61.0 [8.4] kg) were randomly allocated into 2 different feedback conditions, or a condition without feedback (NoFb), as a crossover, repeated-measures design. In one feedback condition, the swimmers were provided with lap completion times as KR. The other feedback condition was athlete-driven, where the swimmers were asked to estimate their lap completion times, and the investigators responded on whether their actual sprint times were faster (promotion-oriented), slower (change-oriented), or the same.
Results: The results showed significantly faster average completion times during the repeated-sprint swim protocol in the athlete-driven KR (P = .014) and KR condition (P = .023), when compared with the NoFb condition. However, significantly faster best completion time was only found in the KR condition (P = .012), when compared with the NoFb condition. Furthermore, the stroke rate was significantly greater during the athlete-driven KR (P = .009) and KR (P = .021) conditions, when compared with the NoFb condition.
Conclusions: The KR condition exhibited the greatest benefit for improving several swimming performance measures during a repeated-sprint protocol, and the increase in stroke rate may have contributed to this performance enhancement. Thus, it is recommended that swimmers receive lap completion times during repeated-sprint training sessions to optimize training quality.
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http://dx.doi.org/10.1123/ijspp.2021-0227 | DOI Listing |
Clin Cancer Res
January 2025
United States Food and Drug Administration, Silver Spring, Maryland, United States.
On April 23, 2024, FDA granted accelerated approval to tovorafenib, a type II RAF kinase inhibitor, for the treatment of patients 6 months of age and older with relapsed or refractory pediatric low-grade glioma (pLGG) harboring a BRAF fusion or rearrangement, or BRAF V600 mutation. Efficacy was evaluated in FIREFLY-1 (NCT04775485), a single-arm, open-label, multicenter trial that enrolled patients 6 months to 25 years of age with relapsed or refractory pLGG with an activating BRAF alteration who had received prior systemic therapy. The major efficacy outcome measure was radiologic overall response rate (ORR), defined as the proportion of patients with complete response, partial response, or minor response as determined by blinded independent central review using Response Assessment in Pediatric Neuro-Oncology (RAPNO) criteria.
View Article and Find Full Text PDFBackground: Pediatric ultrasound (US)-guided percutaneous liver biopsy is a commonly performed procedure in children, and may be performed in a variety of clinical settings. However, there is little research on the relative costs associated with different sedation methods and locations.
Objective: This study uses time-driven activity-based costing (TDABC) to identify relevant costs associated with different biopsy sedation techniques and locations to help inform providers and patients as well as guide value-conscious care.
J Gastrointest Cancer
January 2025
MM Medical College Sadopur, Haryana, India.
Purpose: Neoadjuvant chemotherapy followed by esophagectomy is the usual approach to manage esophageal squamous cell carcinoma (ESCC). The optimal interval to operate after completion of neoadjuvant chemoradiotherapy (NACRT) still remains controversial.
Methods: A prospective study was conducted to observe and compare postoperative complications and pathological outcomes in patients with squamous cell carcinoma of the esophagus who underwent NACRT followed by surgery within 8 weeks or after 8 weeks of NACRT completion.
Ann Surg Oncol
January 2025
Department of Surgery, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
Background: Benefits of neoadjuvant treatment for pancreatic cancer with major vessel invasion has been demonstrated through randomized controlled trials; however, the optimal neoadjuvant treatment strategy remains controversial, especially for radiotherapy. Therefore, we aimed to evaluate the efficacy and safety of neoadjuvant radiotherapy followed by chemotherapy and the optimal time interval to undergo surgery after radiotherapy in (borderline) resectable pancreatic cancer.
Methods: Between 2013 and 2022, patients with (borderline) resectable pancreatic cancer with vessel contact who received 5-fluorouracil with leucovorin, oxaliplatin, and irinotecan or gemcitabine and nanoparticle albumin-bound paclitaxel as initial treatment following surgery were included.
Strahlenther Onkol
January 2025
Department of Radiation Oncology, University Hospital Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Background: Preoperative chemoradiotherapy combined with total mesorectal excision (TME) is a standard treatment for locally advanced rectal cancer (LARC). However, lateral pelvic lymph nodes (LPLNs) are often inadequately treated with standard regimens. This study examines the treatment and postoperative outcomes in LARC patients receiving a simultaneous integrated boost (SIB) for LPLNs during long-course chemoradiotherapy.
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