Enantioselective Cu-catalyzed C-O cross coupling reactions yielding atropisomeric resorcinol-bearing quinazolinones have been developed. Utilizing a new guanidinylated dimeric peptidic ligand, a set of products were generated in good yields with excellent stereocontrol. The transformation was readily scalable, and a range of product derivatizations were performed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968294 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.1c04266 | DOI Listing |
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