AI Article Synopsis
- The article discusses the design and biological properties of a fluorescent compound called BODIPYmyrt, which is made from a specific monoterpenoid and a fluorophore.
- BODIPYmyrt has a high quantum yield (close to 100%) in the 515-518 nm range, indicating its effectiveness in fluorescence applications.
- It can penetrate bacterial and fungal cell membranes, making it useful for studying various types of bacteria and fungi, and also shows potential for targeting subcellular structures like mitochondria in mammalian cells.
Article Abstract
This article describes the design and biological properties of a BODIPY FL-labeled monoterpenoid BF--(4-((1″)-6″,6″-dimethylbicyclo[3.1.1]hept-2″-ene-2″)yl-methoxycarbonylpropyl)-3,3',5,5'-tetramethyl-2,2'-dipyrromethene conjugate (BODIPYmyrt). The fluorophore was characterized using X-ray, NMR, MS, and UV/vis spectroscopy. The conjugate exhibits a high quantum yield (to ∼100%) in the region 515-518 nm. BODIPYmyrt effectively penetrates the membranes of the bacterial and fungal cells and therefore can be used to examine the features of a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi as well. Moreover, BODIPYmyrt exhibits a moderate tropism to the subcellular structures in mammalian cells (e.g., mitochondria), thereby providing an attractive scaffold for fluorophores to examine these particular organelles.
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| http://dx.doi.org/10.1021/acsabm.1c00550 | DOI Listing |
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