Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant.

J Biosaf Biosecur

Research Institute of Public Health, Nankai University, Tianjin, PR China.

Published: June 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we analyzed the mutational profiles of several variants, including the per-site mutation rate, to determine evolutionary relationships. The Omicron variant was found to have a unique mutation profile when compared with that of other SARS-CoV-2 variants, containing mutations that are rare in clinical samples. Moreover, the presence of five mouse-adapted mutation sites suggests that Omicron may have evolved in a mouse host. Mutations in the Omicron receptor-binding domain (RBD) region, in particular, have potential implications for the ongoing pandemic.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718870PMC
http://dx.doi.org/10.1016/j.jobb.2021.12.001DOI Listing

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