AI Article Synopsis
- T cell responses are crucial for viral immunity, helping to generate strong antibody responses, establish immune memory, and clear viruses.
- Inefficient T cell responses can contribute to severe cases of COVID-19, with notable variations in immune responses observed among men, children, and different T cell subsets.
- Vaccines can successfully trigger SARS-CoV-2-specific T cell responses, and natural infection can improve this response, offering crossprotection against variants due to conserved epitopes.
Article Abstract
T cell responses are a key cornerstone to viral immunity to drive high-quality antibody responses, establishing memory for recall and for viral clearance. Inefficient recruitment of T cell responses plays a role in the development of severe COVID-19 and is also represented by reduced cellular responses in men, children, and diversity compared with other epitope-specific subsets and available T cell receptor diversity. SARS-CoV-2-specific T cell responses are elicited by multiple vaccine formats and augmented by prior infection for hybrid immunity. Epitope conservation is relatively well-maintained leading to T cell crossreactivity for variants of concern that have diminished serological responses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739267 | PMC |
| http://dx.doi.org/10.3389/fmed.2021.793102 | DOI Listing |
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