Background: Since 2017, five Indian centres have enrolled into the International Hip Dysplasia Registry for prospective collection of data on Developmental Dysplasia of Hip (DDH).
Aims: To assess how baseline patient characteristics and initial treatment modalities differ across these five centres.
Methods: Registry data collected over 3 years were analyzed. Children with DDH that had radiograph-based diagnoses were included.
Results: Collectively, there were 234 hips (181 patients), of which 218 had undergone surgery. Overall, median age at presentation was 25.3 months (IQR 16.8-46.0); female/male ratio was 2.6:1 (range 1.46-4.75:1); with 42%, 29%, and 29% unilateral left, bilateral and unilateral right hip dislocations respectively. Most were IHDI grade III and IV dislocations (94%). Closed reduction was performed at all but one centre, at median 15.3 months (IQR 9.6-21.1). Open reduction (OR) as a stand-alone procedure was performed at all centres, at median 20.8 months (IQR 15.4-24.9). Combination of OR with a single osteotomy, femoral (FO) or acetabular (AO), was performed at all centres at median 29.7 months (IQR 22.1-43.5). However, for the same age group, three centres exclusively performed FO, whereas the other two exclusively performed AO. The combination of OR with both FO and AO was used at all centres, at median 53.4 months (IQR 42.1-70.8).
Conclusions: The preliminary findings of this multi-centre study indicate similar patient demographics and diagnoses, but important differences in treatment regimens across the five Indian centres. Comparison of treatment regimens, using the 'centre' as a predictive variable, should allow us to identify protocols that give superior outcomes.
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http://dx.doi.org/10.1007/s43465-021-00516-0 | DOI Listing |
Indian J Pediatr
January 2025
Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.
Trop Anim Health Prod
January 2025
School of Molecular Diagnostics, Prophylaxis, and Nanobiotechnology, ICAR- Indian Institute of Agricultural Biotechnology, Garkhtanga, Ranchi, 834003, Jharkhand, India.
Climate change poses significant challenges to livestock production worldwide. Wherein, it affects communities in developing nations primarily dependent on agriculture and animal husbandry. Its direct and indirect deleterious effects on agriculture and animal husbandry includes aberrant changes in weather patterns resulting in disturbed homeorhetic mechanism of livestock vis a vis indirectly affecting nutrient composition of feed and fodder.
View Article and Find Full Text PDFSmall
January 2025
Department of Chemistry, Indian Institute of Technology-Guwahati, Guwahati, Assam, 781039, India.
The design of electrically conductive textiles appears to be a promising approach to combat the existing challenge of deaths caused by severe cold climates around the globe. However, reports on the scalable fabrication of tolerant conductive textiles maintaining a low electrical resistance with an ability for unperturbed and prolonged performance are scarce. Here, a breathable and wrappable water-repellent conductive textile (water-repellent CT) with electrothermal and photothermal conversion abilities at low external voltage and in weak solar light is introduced, respectively.
View Article and Find Full Text PDFSemin Ophthalmol
January 2025
Department of Glaucoma, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, India.
Purpose: To assess the practice patterns among the Indian Pediatric Glaucoma Society (IPGS) members in the management of children with primary congenital glaucoma (PCG).
Methods: An anonymous 74-question survey was administered online via Qualtrics (Qualtrics, Provo, Utah, USA) using a link sent by email to the 88 IPGS members. The questionnaire comprised five sections and was designed to gather information regarding respondent demographics and specialty training, clinic composition and volume, surgical practices and preferences, follow-up practices, and additional services.
J Pathol
January 2025
The Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
Spatial transcriptomics (ST) offers enormous potential to decipher the biological and pathological heterogeneity in precious archival cancer tissues. Traditionally, these tissues have rarely been used and only examined at a low throughput, most commonly by histopathological staining. ST adds thousands of times as many molecular features to histopathological images, but critical technical issues and limitations require more assessment of how ST performs on fixed archival tissues.
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