High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses.

Physiology (Bethesda)

Laboratorio de Fisiología Comparada/Laboratorio de Fisiología del Transporte de Oxígeno, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.

Published: July 2022

AI Article Synopsis

  • Erythrocytosis refers to the increased production of red blood cells, which is commonly observed in high-altitude populations.
  • While having more red blood cells can improve oxygen delivery and is helpful in high-altitude environments,
  • excessive erythrocytosis may result in health issues, such as chronic mountain sickness (CMS), which can be detrimental to individuals.

Article Abstract

Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O-carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as chronic mountain sickness (CMS).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191173PMC
http://dx.doi.org/10.1152/physiol.00029.2021DOI Listing

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