<b>Background and Objective:</b> Andaliman is a wild plant in Indonesia and it has been used for centuries as traditional medicine. This study aimed to evaluate the effect of methanol extract of andaliman on apoptosis cancer cells via cytochrome c protein. <b>Materials and Methods:</b> The rats are divided into 5 groups. K: Control, K<sub>+</sub>: Cancer model rats, P<sub>1</sub>: A dose of 100 mg/b.wt./day of andaliman, P<sub>2</sub>: A dose of 200 mg/b.wt./day and P<sub>3</sub>: A dose of 400 mg/kg/b.wt./day for 30 days. The rats were dissected, then the cervical tissue was prepared on paraffin blocks, given Immunohistochemistry staining with cytochrome c antibody. <b>Results:</b> There was a significant difference in body and cervical weight (p<0.01). The histology also showed a significant difference between each treatment (p<0.01) in cytochrome c. The highest cytochrome c expression was at P<sub>2</sub> and the lowest was at K<sub>-</sub>. <b>Conclusion:</b> Andaliman methanol extract can thus be developed into a cervical cancer drug candidate because it can reduce the positive index of cytochrome c in cervical histology.
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