[NEUROPSYCHOLOGICAL ANALYSIS OF DISORDERS OF HIGHER MENTAL FUNCTIONS IN PATIENTS WITH DIFFERENT TYPES OF MULTIPLE SCLEROSIS].

Patients with RR (n=45) and SP (n=24) types of multiple sclerosis (MS) were analyzed using original Luria neuropsychological battery. On the basis of the results obtained, the general characteristics of neuropsychological syndromes were determined: asthenic manifestations; certain violations of the auditory-speech memory; decreased visual memory; disorders of interhemispheric somatosensory transfer; violations of the simultaneous factor of the mental activity organization. It is shown that the progressive type of MS is characterized by a significantly greater degree of severity of the above disorders, as well as their certain qualitative features: a wider range of mnestic disorders; the presence of disturbances in the interhemispheric transfer of motor information; the presence of violations of the assessment of rhythmic sequences by ear; the presence of visual-constructive activity disorders. The factors that determine the neuropsychological syndrome structure in both categories of patients include: the activation factor associated with the work of nonspecific brain systems at all levels of organization, the factor of the simultaneous organization of mental activity associated with the work of the parietotemporal-occipital parts of the cerebral cortex, the factor of interhemispheric interaction. The qualitative differences between the groups of patients consist in the different influence of these factors on the formation of the structure of disorders.