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Inflammation and the Link to Vascular Brain Health: Timing Is Brain. | LitMetric

Inflammation and the Link to Vascular Brain Health: Timing Is Brain.

Stroke

Department of Neurology, David Geffen School of Medicine, University of California Los Angeles.

Published: February 2022

AI Article Synopsis

  • Inflammation is crucial in both causing and affecting brain health, especially in relation to vascular injuries like those seen during the COVID-19 pandemic.
  • Recent studies highlight how different inflammatory pathways play unique roles in various phases of cerebrovascular health, including risk for stroke and stages of recovery.
  • Understanding the complex nature of inflammation in these conditions is key for developing effective treatments aimed at preventing and repairing vascular brain injuries.

Article Abstract

Inflammation and its myriad pathways are now recognized to play both causal and consequential roles in vascular brain health. From acting as a trigger for vascular brain injury, as evidenced by the COVID-19 pandemic, to steadily increasing the risk for chronic cerebrovascular disease, distinct inflammatory cascades play differential roles in varying states of cerebrovascular injury. New evidence is regularly emerging that characterizes the role of specific inflammatory pathways in these varying states including those at risk for stroke and chronic cerebrovascular injury as well as during the acute, subacute, and repair phases of stroke. Here, we aim to highlight recent basic science and clinical evidence for many distinct inflammatory cascades active in these varying states of cerebrovascular injury. The role of cerebrovascular infections, spotlighted by the severe acute respiratory syndrome coronavirus 2 pandemic, and its association with increased stroke risk is also reviewed. Rather than converging on a shared mechanism, these emerging studies implicate varied and distinct inflammatory processes in vascular brain injury and repair. Recognition of the phasic nature of inflammatory cascades on varying states of cerebrovascular disease is likely essential to the development and implementation of an anti-inflammatory strategy in the prevention, treatment, and repair of vascular brain injury. Although advances in revascularization have taught us that time is brain, targeting inflammation for the treatment of cerebrovascular disease will undoubtedly show us that timing is brain.

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Source
http://dx.doi.org/10.1161/STROKEAHA.121.032613DOI Listing

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