AI Article Synopsis
- Superior sulcus tumors (SSTs) are challenging lung cancers, prompting a trial to assess a new treatment involving an immune-checkpoint inhibitor, durvalumab, after chemoradiotherapy (CRT) in patients with resectable SSTs.
- The trial focuses on measuring 3-year overall survival, with patients undergoing CRT followed by surgery and multiple courses of durvalumab.
- Initial safety assessments showed no significant issues, and patient enrollment is ongoing to further explore the treatment's efficacy and potential as a new standard care for SST.
Article Abstract
Background: Superior sulcus tumours (SSTs) are relatively uncommon and one of the most intractable lung cancers among non-small cell lung cancer (NSCLC). We planned a multicenter, single-arm confirmatory trial of new multidisciplinary treatment using immune-checkpoint inhibitor. The aim is to evaluate the safety and efficacy of new multidisciplinary treatment with perioperative durvalumab after chemoradiotherapy (CRT).
Methods: The primary endpoint is 3-year overall survival. Patients receive induction CRT with sequential two courses of durvalumab, followed by surgical resection for resectable SST. The regimen for CRT is two courses of cisplatin and S-1, and concurrent radiotherapy (66 Gy/33 Fr). After surgery, 22 courses of post-operative durvalumab therapy are administered. For unresectable SST, an additional 22 courses of durvalumab are administered after induction durvalumab.
Results: In two cases as a safety cohort, the safety of intervention treatment up to 30 days after surgery was examined, and there were no special safety signals. Patient enrollment has now resumed in the main cohort.
Conclusions: The results of this study may contribute to the establishment of a new standard of care for SST, which is an intractable NSCLC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985519 | PMC |
| http://dx.doi.org/10.1093/jjco/hyab208 | DOI Listing |
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