Accumulation characteristics of polychlorinated dibenzo-p-dioxins and dibenzofurans and polychlorinated biphenyls in human breast milk from a seaside city of North China.

Breast milk samples were collected from 51 mothers in a seaside city Dalian, where the residents usually have higher dietary exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) due to the larger consumption of seafood. The lipid-basis concentrations of ∑ClDD/Fs, ∑ClBs, and total toxicity equivalent (WHO-TEQ) were measured to be in the ranges of 35.7-2727.8 pg/g, 4.91-52.64 ng/g, and 2.27-36.30 pg/g, respectively. The average proportion of ∑ClDD/Fs was higher than that of ∑ClDD/Fs in the collected human breast milk samples, suggesting that the health risk of ClDD/Fs should be especially concerned. The concentration data of PCDD/Fs and PCBs in human breast milk essentially followed a positive skew probability distribution. Women in high-level exposure scenarios exhibited a higher potential to accumulate homologues ClDFs, ClDFs, ClDF, and ClBs in breast milk. Three PCDD/F congeners (1,2,3,6,7,8-ClDF, 1,2,3,4,7,8-ClDF, and 1,2,3,4,6,7,8-ClDD) and three PCB congeners (PCB 126, PCB 138, and PCB 169) were identified as good indicators for the accumulation of PCDD/Fs and PCBs in human breast milk, respectively. The food-to-milk accumulation factors (FMAF) were calculated to evaluate the accumulation potentials of different PCDD/F and PCB congeners in human breast milk via dietary exposure. The calculated FMAF value presented a non-monotonic variation with the logarithm of n-octanol-water partition coefficient (log K) with a peak at a log K value of about 7.3 and a valley at a log K value of about 8. The mean value of the estimated daily intake (EDI) of total WHO-TEQ for breast-fed infants in Dalian, predicted by Monte Carlo simulation, was 10 folds higher than the upper range of the tolerable daily intake (TDI) value (4 pg WHO-TEQ/kg bw/d), suggesting continued and enhanced efforts should be made to reduce the exposure risk of infants to PCDD/Fs and PCBs.