AI Article Synopsis
- Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting women of reproductive age, and the study aimed to create a better animal model for PCOS by combining letrozole (LET) treatment with a high-fat diet (HFD).
- The results showed that both the LET and LET + HFD groups developed ovarian cysts and had hormonal imbalances, with higher testosterone but lower estradiol and progesterone levels.
- The LET + HFD group exhibited significant metabolic changes, such as increased body weight and altered blood markers, suggesting it is a more accurate representation of the metabolic issues seen in human PCOS compared to the LET-only model, which lacked these metabolic anomalies.
Article Abstract
Polycystic ovary syndrome (PCOS) is one of the most prevalent hormonal disorders in women of reproductive age. Letrozole (LET)-induced PCOS is a good model but has drawbacks such as the absence of metabolic changes. Hence, in the present study, we aimed to develop a new animal model combining a high-fat diet (HFD) and LET. Female Wistar rats were divided into a control group, LET group, and LET + HFD (45% energy from fat) group. Compared with the control group, the LET and LET + HFD groups showed ovarian cysts and elevated testosterone levels, whereas oestradiol and progesterone levels were reduced. The LET + HFD group displayed significant changes in body weight, as well as in levels of triglycerides, fasting blood glucose, direct bilirubin, alanine aminotransferase, and uric acid; in terms of glucose intolerance and insulin resistance, the LET + HFD group showed better results than the LET group. Compared with the control group, elevated levels of tumour necrosis factor-α were detected in both the LET and LET + HFD groups. The addition of HFD to the LET model afforded good metabolic aberrations, along with ovarian cysts. In contrast, the LET-only model failed to demonstrate metabolic anomalies observed in the human PCOS condition.
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| http://dx.doi.org/10.1016/j.ejphar.2022.174746 | DOI Listing |
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