AI Article Synopsis
- Multiparametric autoantibody tests are proposed to enhance the accuracy and speed of diagnosing autoimmune diseases (AID) compared to traditional single-antigen tests.
- These multiplex tests can analyze multiple autoantibodies at once, simplifying laboratory processes and improving diagnostic sensitivity.
- They not only aid in diagnosis but can also help predict AID onset, identify clinical phenotypes, determine prognosis, and potentially indicate responses to specific treatments, moving towards personalized medicine in the field.
Article Abstract
Background: The introduction of multiparametric autoantibody tests has been proposed to improve the accuracy of the immunological diagnosis of autoimmune diseases (AID) and to accelerate time for completing the diagnostic process. Multiplex tests are capable of detecting many autoantibodies in a single run whereas a traditional immunoassay uses a single antigen to detect only a single specificity of autoantibodies. The reasons why multiplex tests could replace conventional immunoassays lie in the evidence that they allow for more efficient handling of large numbers of samples by the laboratory, while ensuring greater diagnostic sensitivity in AID screening.
Content: This review aims to highlight the important role that multiparametric tests could assume when designed for defined profiles they are used not only for diagnostic purposes but also to predict the onset of AID to identify clinical phenotypes and to define prognosis. Furthermore, differences in the antibody profile could identify which subjects will be responsive or not to a specific pharmacological treatment.
Summary: The use of autoantibody profiles, when specifically requested and performed with clinically validated technologies, can represent a significant step toward personalized medicine in autoimmunology.
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| http://dx.doi.org/10.1093/jalm/jfab132 | DOI Listing |
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