Background And Aims: We aimed to determine the cause of non-secondary hyperparathyroidism (Non-SHPT) in Indian postmenopausal women.
Materials & Methods: 334 apparently healthy postmenopausal women were assessed for bone mineral homeostaisis including Vitamin D, PTH and VDR polymorphism.
Results: 83% of the subjects had vitamin D deficiency further associated with VDR gene polymorphism (P 0.000). A sizable number of subjects (N = 83) did evoke SHPT despite low vitamin D levels. We observe that VDR gene polymorphism was strongly associated in the sub-group of non-SHPT.
Conclusion: lack of SHPT warrants researchers to study the pathophysiology of non-SHPT in detail to substantiate our findings.
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| http://dx.doi.org/10.1016/j.dsx.2021.102381 | DOI Listing |
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