Elizabeth Crosby (1888-1983) is a beloved and well-respected titan of neuroanatomy. Her contributions to our understanding of neuroanatomy are rooted in her seminal text, The Comparative Anatomy of the Nervous System of Vertebrates, Including Man, published in 1936, which is a masterful and comprehensive account of comparative neuroanatomy. Her later texts, Correlative Neurosurgery and Correlative Anatomy of the Nervous System, are standard reference texts to this day. Her mentorship of graduate students, close work with the University of Michigan neurosurgery department, and the quality of her research and scientific publications were recognized with many awards, culminating in the National Medal of Science presented by President Carter in 1980.
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REsolution of Symptoms afTer Oesophago-gastric cancer REsection delphi (RESTOREd)-standardizing the definition, investigation and management of gastrointestinal symptoms and conditions after surgery.
Br J Surg
November 2024
Department of Gastroenterology, United Lincolnshire Hospitals NHS Trust, Lincoln, UK.
Background: Oesophago-gastric cancer surgery negatively affects quality of life with a high postoperative symptom burden. Several conditions that may be diagnosed and treated after surgery are recognised. However, consensus regarding their definition and management is lacking.
View Article and Find Full Text PDFClassification of variants of reduced penetrance in high-penetrance cancer susceptibility genes: Framework for genetics clinicians and clinical scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK).
Genet Med
October 2024
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom; The Royal Marsden NHS Foundation Trust, Fulham Road, London, United Kingdom. Electronic address:
Purpose: Current practice is to report and manage likely pathogenic/pathogenic variants in a given cancer susceptibility gene as though having equivalent penetrance, despite increasing evidence of intervariant variability in risk associations. Using existing variant interpretation approaches, largely based on full-penetrance models, variants in which reduced penetrance is suspected may be classified inconsistently and/or as variants of uncertain significance. We aimed to develop a national consensus approach for such variants within the Cancer Variant Interpretation Group UK (CanVIG-UK) multidisciplinary network.
View Article and Find Full Text PDFThe PS4-likelihood ratio calculator: flexible allocation of evidence weighting for case-control data in variant classification.
J Med Genet
September 2024
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK
Background: The 2015 American College of Medical Genetics/Association of Molecular Pathology (ACMG/AMP) variant classification framework specifies that case-control observations can be scored as 'strong' evidence (PS4) towards pathogenicity.
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Prevalence and Risk Factors for Malignant Nodal Involvement in Early esophago-gastric Adenocarcinoma: Results from the Multicenter Retrospective Congress Study (endosCopic resectiON, esophaGectomy or Gastrectomy For Early Esophagogastric Cancers).
Ann Surg
September 2024
Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK.
Article Synopsis
- The study investigated the risks of lymph node metastasis (LNM) and treatment outcomes in patients with early esophago-gastric (EG) adenocarcinoma, focusing on the effectiveness of endoscopic resection (ER) versus radical surgery.
- A retrospective analysis was conducted using data from 1,601 patients across 26 UK centers, revealing that the overall LNM rate was 13.5% and highlighting certain tumor characteristics that may indicate higher risks, although these factors did not predict LNM rates or survival outcomes significantly.
- The findings suggest a need to reevaluate the predictive factors for LNM in early EG adenocarcinoma and emphasize the importance of further research to better identify patients suitable for either organ-preserving
Childhood myopia and the coronavirus disease 2019 pandemic: Lessons for future pandemics.
Taiwan J Ophthalmol
May 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
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