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Enhanced detection of Brain-Derived Neurotrophic Factor (BDNF) using a reduced graphene oxide field-effect transistor aptasensor.
Nanoscale
January 2025
James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK.
Neurodegenerative diseases, characterized by the progressive deterioration of neuronal function and structure, pose significant global public health and economic challenges. Brain-Derived Neurotrophic Factor (BDNF), a key regulator of neuroplasticity and neuronal survival, has emerged as a critical biomarker for various neurodegenerative and psychiatric disorders, including Alzheimer's disease. Traditional diagnostic methods, such as Enzyme-Linked Immunosorbent Assay (ELISA) and electrochemiluminescence (ECL) assays, face limitations in terms of sensitivity, stability, reproducibility, and cost-effectiveness.
View Article and Find Full Text PDFLanthanide-Assisted Function Tailoring of the HOF-Based Logic Gate Sensor Array for Biothiol Detection and Disease Discrimination.
Anal Chem
January 2025
Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Box 332, Shenyang 110819, China.
The advancement of lanthanide fingerprint sensors characterized by targeted emission responses and low self-fluorescence interference for the detection of biothiols is of considerable importance for the early diagnosis and treatment of cancer. Herein, the lanthanide "personality function tailoring" HOF composite sensor array is designed for the specific discrimination of biothiols (GSH, Cys, and Hcy) based on the activation of various luminescent molecules, such as r-AuNCs/luminol via HOF surface proximity. Lumi-HOF@Ce serves as a versatile platform for catalyzing the oxidation of -phenylenediamine (OPD) to generate yellow fluorescent oligomers, accompanied by the fluorescence attenuation of luminol.
View Article and Find Full Text PDFHyaluronic acid/silk fibroin nanoparticles loaded with methotrexate for topical treatment of psoriasis.
Int J Pharm X
June 2025
State Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Sciences, Yibin Academy, Southwest University, Chongqing 400715, China.
Systemic administration of methotrexate (MTX), widely regarded as one of the most effective treatments for psoriasis, poses significant challenges due to its high toxicity, limited solubility, and potential for adverse effects. Consequently, developing a topical form of MTX may offer a safer and more effective strategy for psoriasis management. Silk fibroin (SF), a protein-based biomacromolecule, has shown considerable promise as a nanocarrier for sustained and targeted drug delivery, owing to its exceptional physicochemical and biological properties.
View Article and Find Full Text PDFSmart Bioelectronic Nanomesh Face Masks with Permeability and Flexibility for Monitoring Cortisol in Saliva.
ACS Sens
January 2025
School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, Republic of Korea.
Bioelectronic face masks can easily collect biomarkers in saliva, in which free cortisol is abundant. However, conventional bioelectronic face masks involve significant challenges in terms of permeability and inhalation due to their nonpermeable film-type structure. Herein, we introduce a flexible and permeable nanomesh-based wearable biosensor designed for bioelectronic face masks that monitor cortisol levels.
View Article and Find Full Text PDFLow-Temperature Growth of Centimeter-Sized 2D PdSe by Self-Limiting Liquid-Phase Edge Epitaxy.
J Am Chem Soc
January 2025
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Two-dimensional (2D) PdSe atomic crystals hold great potential for optoelectronic applications due to their bipolar electrical characteristics, tunable bandgap, high electron mobility, and exceptional air stability. Nevertheless, the scalable synthesis of large-area, high-quality 2D PdSe crystals using chemical vapor deposition (CVD) remains a significant challenge. Here, we present a self-limiting liquid-phase edge-epitaxy (SLE) low-temperature growth method to achieve high-quality, centimeter-sized PdSe films with single-crystal domain areas exceeding 30 μm.
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