AI Article Synopsis
- The study investigates the potential of netzahualcoyonol, a compound from plant roots, as an antibacterial agent against resistant bacteria and biofilm formation.
- It demonstrates that netzahualcoyonol is effective in inhibiting the growth of Gram-positive bacteria and disrupting biofilm, with a synergistic effect when paired with other antibiotics.
- The compound shows low cytotoxicity, indicating it may be a safe and promising option for developing new antimicrobials.
Article Abstract
The expression of virulence factors, such as biofilm formation, in association with the acquisition of resistance to multiple drugs, has evidenced the need for new and effective antimicrobial agents against . The evaluation of the pharmacological properties of plant-derived compounds is a promising alternative to the development of new antimicrobials. In this study, we aimed to evaluate the antibacterial, antibiofilm, and the synergistic and cytotoxic effects of netzahualcoyonol isolated from (Lam.) DC. roots. Netzahualcoyonol presented bacteriostatic (1.56-25.0 µg/mL) and bactericidal (25.0-400.0 µg/mL) effects against Gram-positive bacteria, disrupted the biofilm of and presented a synergistic effect after its combination with β-lactams and aminoglycosides. The low cytotoxicity of netzahualcoyonol (Selectivity Index (SI) for (2.56), (20.56), and (1.28)) suggests a good security profile. Taken together, these results show that netzahualcoyonol is promising for the development of a new effective antibacterial agent.
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| http://dx.doi.org/10.1080/14786419.2021.2023865 | DOI Listing |
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