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Contrasting Molecular Imaging Findings in Hepatocellular Carcinoma Using Dual Positron Emission Tomography Modalities.
Cureus
December 2024
Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, JOR.
Fibroblast activation protein (FAPI) has been recently incorporated as a molecular imaging radiotracer for the evaluation of epithelial neoplasms that support or complement the role of [F]Fluorodeoxyglucose ([F]FDG) in many cancer subtypes since its development. Both radiotracers have been shown to have diagnostic, prognostic, and predictive value for several neoplasms. Herein, we present a 73-year-old male patient with a complex medical and oncological history who was recently diagnosed with hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFCurrent status of FAP-directed cancer theranostics: a bibliometric analysis.
Biophys Rep
December 2024
Department of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Development and Translation of Radiopharmaceuticals, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China.
Fibroblast activation protein (FAP) is a key molecule in the field of oncology, with significant impacts on tumor diagnosis and treatment. Importantly, it has paved the way for the development of radiotracers for quinoline-based FAP inhibitors (FAPIs), which are currently among the most promising radiotracers for PET imaging in cancer. We performed a bibliometric analysis of scientific publications related to FAP and FAPI-based radiotracers, which included the quantification and visualization of current research trends and prospects based on various bibliometric indicators.
View Article and Find Full Text PDFGa-DOTA-FAPI-04 and F-FDG PET/CT: a head-to-head comparison for peritoneal carcinomatosis diagnostic accuracy.
Abdom Radiol (NY)
January 2025
Department of Nuclear Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, 050011, Hebei, China.
Purpose: The study aimed to compare the diagnostic accuracy of Ga-DOTA-FAPI-04 (Ga-FAPI) and F-FDG PET/CT for peritoneal carcinomatosis (PC) in patients with various types of cancer.
Methods: The study enrolled 113 patients with suspected peritoneal malignancy, each of whom underwent Ga-FAPI and F-FDG PET/CT scans. Lesions in all patients were confirmed through pathology or radiological follow-up.
Comparison of diagnostic performance of [Ga]-Ga-FAPI-46 and [F]-FDG PET/CT imaging for the detection of lesions and disease staging in patients with breast cancer.
Asia Ocean J Nucl Med Biol
January 2025
Research Center for Nuclear Medicine, Shraiati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study aimed to compare the effectiveness of [Ga]-Ga-FAPI-46 and [F]-FDG PET/CT imaging in detecting lesions and staging breast cancer.
- Twelve female breast cancer patients underwent both imaging tests, revealing that while both methods had similar overall lesion detection rates and disease staging, [Ga]-Ga-FAPI-46 indicated an improved tumor-to-background ratio and showed better uptake in certain areas like the brain and lymph nodes for some patients.
- The preliminary findings suggest that [Ga]-Ga-FAPI-46 may offer advantages in identifying tumors due to its lower uptake in healthy organs, potentially leading to more effective diagnostic applications in the future.
Assessment of fully quantitative and simplified methods for analysis of [Ga]Ga-FAPI-46 uptake in patients with pancreatobiliary cancer using LAFOV PET/CT.
Eur J Nucl Med Mol Imaging
January 2025
Amsterdam UMC location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Article Synopsis
- The study aimed to validate simpler methods for measuring [Ga]Ga-FAPI-46 uptake by comparing them to comprehensive pharmacokinetic modeling.
- Ten patients with pancreatobiliary cancer participated in a 90-minute dynamic PET/CT scan, and various methods, including plasma-input tissue-compartment models, were used to assess the uptake of the compound in lesions.
- The results indicated that image-based target-to-whole blood ratio (TBR) and mean standardized uptake values (SUVmean) at 60-70 minutes post-injection are effective and reliable for quantifying [Ga]Ga-FAPI-46 uptake.
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