Background: Aortitis refers to pathologic inflammation of the aortic wall and is broadly categorized into inflammatory (or non-infectious) and infectious aortitis. While rare, isolated non-infectious ascending aortitis (I-NIAA) is a clinical entity that is becoming increasingly recognized but remains poorly understood.
Case Summary: A 72-year-old man presented with an asymptomatic murmur and was found to have severe aortic insufficiency second to a large ascending aortic aneurysm. He underwent surgical repair and pathology revealed isolated non-infectious ascending aortitis. Following successful surgical repair, he developed joint pains which were successfully treated with glucocorticoids.
Discussion: Isolated non-infectious aortitis is a rare entity that warrants further investigation. This case highlights the importance of sending surgical specimens for histopathologic evaluation even when a systemic process is not evident at the time of surgical repair. The development of systemic symptoms following surgical repair in this patient emphasizes the importance of thorough rheumatologic evaluation in patients found to have I-NIAA. Isolated non-infectious ascending aortitis remains poorly understood, and further study is needed to evaluate both its existence as a distinct clinical entity and the role of immunosuppressive therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728718 | PMC |
| http://dx.doi.org/10.1093/ehjcr/ytab427 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mechanical Aortic Valve Dehiscence and Aortic Root Aneurysm: An Interesting Case With a Timely Diagnosis and Intervention.
Cureus
June 2024
Cardiology, Piedmont Heart Institute, Fayetteville, USA.
Article Synopsis
- * Common risk factors include infections, aortic aneurysms, and severe calcification, with conditions like ankylosing spondylitis and vasculitis also contributing.
- * Diagnosis usually involves echocardiography, and additional tests like CT scans can help; quick diagnosis and surgery are essential for better recovery outcomes.
The NLRP3 Inflammasome Is Dispensable in Methicillin-Resistant Urinary Tract Infection.
Pathogens
January 2024
Department of Biology, University of Louisiana at Lafayette, Lafayette, LA 70504, USA.
The NLRP3 inflammasome is a cytoplasmic complex that senses molecular patterns from pathogens or damaged cells to trigger an innate immune defense response marked by the production of proinflammatory cytokines IL-1β and IL-18 and an inflammatory death called pyroptosis. The NLRP3 inflammasome is activated in the urinary tract by a variety of infectious and non-infectious insults. In this study, we investigated the role of the NLRP3 inflammasome by comparing the pathophysiology of methicillin-resistant (MRSA) ascending UTI in wild-type (WT) and mice.
View Article and Find Full Text PDFImmune-Mediated Non-Infectious Periaortitis After Aortic Graft Replacement Surgery: A Case Report Highlighting the Need for Immunosuppressive Therapy.
Am J Case Rep
December 2023
Department of Cardiovascular Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Chiba, Japan.
Article Synopsis
- - A 49-year-old man experienced fever, malaise, and high C-reactive protein levels after having an aortic graft replaced for dissection, indicating a non-infectious inflammatory reaction that typically resolves without treatment.
- - Despite initial improvement with colchicine and prednisolone, his symptoms returned and he suffered a stroke due to complications linked to the graft, requiring surgical repair.
- - The case highlights the importance of recognizing non-infectious periaortitis as a potential post-surgery complication, which may demand immunosuppressive therapy to avoid serious issues like pseudoaneurysm and graft failure.
Giant-Cell Aortitis-Induced Acute Aortic Insufficiency: An Underestimated Etiology.
Am J Case Rep
June 2023
Department of Pathology, Rutgers Barnabas Health System/Newark Beth Israel Medical Center, Newark, NJ, USA.
BACKGROUND Acute aortic insufficiency can be secondary to multiple conditions, including infective endocarditis, aortic root pathologies (eg, dissection, aortitis), or traumatic injury. Aortitis involves a broad spectrum of disorders characterized by inflammatory changes in the aortic wall. This pathology can be subsequently classified depending on its etiology into inflammatory and infectious causes.
View Article and Find Full Text PDFCauses of pregnancy arrest in the canine species.
Reprod Domest Anim
September 2023
Unité de Médecine de l'Elevage et du Sport (UMES), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.
In the canine species, early pregnancy arrest before 30-40 days of pregnancy will induce intra-uterine embryonic or foetal resorption, with very few clinical signs. If no genital examination by ultrasound is performed at that time, it will often remain unnoticed and the bitch will be qualified as infertile. It is only when pregnancy stops at a later stage, mostly after 40 days, that clinical signs will be seen.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!