Background: SD11 is a probiotic derived from the human oral cavity and has potential being used for dental prophylaxis. The cell free supernatant (CFS) of SD11 has good antimicrobial and antioxidant effects.
Aim: This study aimed to incorporate CFS of the probiotic into thermoresponsive copolymers to create a sol-gel formulation.
Methods: The sol-gel formulation was developed using Poloxamer 407 as the main polymer, which was mixed with natural polymers such as gellan gum, sodium alginate, and xyloglucan in different proportions. The sol-gel formulations were characterized based on their physicochemical parameters such as appearance, pH, viscosity, flow-ability in low temperature, antioxidant and antibacterial activity. An release study was performed using Franz's diffusion cell and the stability was determined under freeze-thaw cycle conditions.
Results: The combination of 15% w/v of poloxamer 407 with 0.5% w/v of sodium alginate was the best sol-gel formulation to deliver the CFS of the probiotic.
Conclusion: This study was successful in creating a sol-gel formulation using a thermoresponsive copolymer, that could efficiently deliver CFS of the probiotic SD11.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725760 | PMC |
| http://dx.doi.org/10.1080/20002297.2021.2012390 | DOI Listing |
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