Background: Sleep comorbidities are common, and sometimes severe, for children with early-life epilepsies (ELEs). Yet, there is a paucity of data regarding the profile of these sleep disturbances and their complications.
Methods: Participants registered with the Rare Epilepsy Network (REN) were queried about sleep via online questionnaires. Descriptive statistics and logistic regression were performed.
Results: Median age of the 356 children was 56 months (interquartile range 30 to 99), 56% were female, and 53% (188/356) endorsed a sleep concern. Frequent nighttime awakenings (157 of 350; 45%), difficulty falling asleep (133 of 350; 38%), and very restless sleep (118 of 345; 34%) were most endorsed. Nocturnal seizures were associated with sleep concerns and were reported in 75% (268 of 356) of children. Of the children with nocturnal seizures, 56% (118 of 268) had sleep concerns. Of the children without nocturnal seizures, 43% (38 of 88) had sleep concerns. Sleep concerns were most common in dup15q syndrome (16 of 19; 84%). Children aged 4 to ≤10 years (adjusted odds ratio [aOR] 16.1; 95% confidence interval [CI] 2.0, 131.0) and 10 to <13 years (aOR 22.2; 95% CI 2.6, 188.6) had a greater odds of having a sleep concern compared with children aged ≤6 months. Female sex appeared protective for sleep concerns (aOR 0.6; 95% CI 0.4, 0.9). The association between sleep concerns and nocturnal seizures was weaker when adjusted for sex and age category in a logistic regression model.
Conclusions: Reported sleep concerns are highly prevalent in children with ELEs and persist with age, in contrast to what is expected in healthy children. There may be unmet sleep-related clinical needs in children with ELEs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857052 | PMC |
| http://dx.doi.org/10.1016/j.pediatrneurol.2021.12.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of a standardized patient-reported clinical questionnaire for children with spinal pain.
BMC Med Res Methodol
January 2025
Medical Spinal Research Unit, Spine Centre of Southern Denmark, University Hospital of Southern Denmark, Kolding, Denmark.
Background: Spinal pain affects up to 30% of school-age children and can interfere with various aspects of daily life, such as school attendance, physical function, and social life. Current assessment tools often rely on parental reporting which limits our understanding of how each child is affected by their pain. This study aimed to address this gap by developing MySpineData-Kids ("MiRD-Kids"), a tailored patient-reported questionnaire focusing on children with spinal pain in secondary care (Danish hospital setting).
View Article and Find Full Text PDFAs a NICU parent, I was always wondering how my daughter could sleep through all of the noise in the NICU what with her very early birth. I was already concerned about her developmental outcomes due to the birth itself, but the alarms and noise in the NICU gave me incredible pause. So when I found about DREAMIES, a product that helps muffle the noise not only in the NICU but during transport and during an MRI, I was amazed.
View Article and Find Full Text PDFThe need for pediatric sleep education to enhance healthcare for children and adolescents: A global perspective from a survey of members of the international pediatric sleep association.
Sleep Med
December 2024
Developmental and Social Psychology, Sapienza University of Rome, Rome, Italy.
Introduction: Sleep concerns have become increasingly common over the past few decades. This study outlines the perceived needs and gaps in pediatric sleep education, drawing insights from a diverse international cohort of pediatric sleep health professionals.
Methods: International Pediatric Sleep Association (IPSA) members were invited to complete an online survey examining a variety of topics related to pediatric sleep education developed by the education committee.
Omega 6 fatty acids: helpful, harmless or harmful?
Curr Opin Clin Nutr Metab Care
December 2024
Nutrition Foundation of Italy, Milan, Italy.
Purpose Of Review: This paper reviews the most recent literature from January 2023 to August 2024 on the physiological effects of n-6 polyunsaturated fatty acids (PUFAs), with a focus on linoleic acid (LA).
Recent Findings: Contrary to previous concerns that high LA intake may increase inflammation, most recent evidence supports the benefits of LA for cardiometabolic health. Several large studies report that higher blood LA levels correlate with reduced risks of coronary heart disease, stroke, and type 2 diabetes.
Clinical Manifestations.
Alzheimers Dement
December 2024
University of California, Berkeley, Berkeley, CA, USA.
Background: Although it has been estimated that modifiable risk factors account for around 40% of population variability in dementia risk, understanding how risk factors are related to one another and to brain pathology and cognition has been challenging. We used a clustering approach to examine patterns of risk factor interrelationships and to investigate how these patterns affect relationships between pathology and cognition.
Method: We collected risk factor data concerning health, lifestyle, sleep, and personality from 149 cognitively normal older adults (73±6.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!