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HHV-6 and Schizophrenia: An Unusual Presentation or an Unproven Etiology?
Prim Care Companion CNS Disord
January 2022
Duke-National University of Singapore (NUS), Singapore.
Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.
Front Microbiol
August 2018
HHV-6 Foundation, Santa Barbara, CA, United States.
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can later be activated causing cognitive and behavioral disturbances. Hence, this study was designed to evaluate possible association of HHV-6A and HHV-6B activation with three different groups of psychiatric patients.
View Article and Find Full Text PDFExposure to Perinatal Infections and Bipolar Disorder: A Systematic Review.
Curr Mol Med
October 2016
Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.
Bipolar disorder (BD) is a debilitating psychiatric disorder and a growing global public health issue. Notwithstanding BD has been conceptualized as a neuroprogressive illness, there are some evidences to suggest a role for neurodevelopmental pathways in the patho-etiology of this disorder. Evidences on the associations between perinatal infections and risk for bipolar disorder have been inconsistent across studies.
View Article and Find Full Text PDFType specific Real time PCR for detection of human herpes virus 6 in schizophrenia and bipolar patients: a case control study.
BMC Psychiatry
November 2015
Department of Psychiatry, Medical School, Iran University of Medical Sciences, Tehran, Iran.
Background: Schizophrenia (SC) and bipolar disorder (BD) are among the most devastating diseases worldwide. There are several lines of evidence suggesting that viruses may play significant roles in the etiology of these mental disorders. The aim of this study was the detection of HHV-6A/B in the peripheral blood mononuclear cells (PBMC) of SC and BD patients versus the healthy control (HC) subjects using a new method of type-specific Real time PCR analysis.
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