Skin interaction, permeation, and toxicity of silica nanoparticles: Challenges and recent therapeutic and cosmetic advances.

Silica nanoparticles (SNPs) received more attention with the emergence of nanotechnology with the aim and promise of becoming innovative drug delivery systems. They have been fulfilling this objective with excellence and nowadays they play a central role in biomedical applications. New SNPs application routes are being explored such as the epidermal, dermal, and transdermal routes. With that, novel models of synthesis, functionalization, and applications constantly appear. However, it is essential that such innovations are accompanied by in-depth studies on permeation, biodistribution, metabolization, and elimination of the generated by-products. Such studies are still incipient, if not rare. This article reviews significant findings on SNPs and their skin interactions. An extensive literature review on SNPs synthesis and functionalization methodologies was performed, as well as on the skin characteristics, skin permeation mechanisms, and in vivo toxicity assessments. Furthermore, studies of the past 5 years on the main therapeutic and cosmetic products employing SNPs, with greater emphasis on in vivo and ex vivo studies were included.