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Association Between Common Variants in the / Genes and Risk for Essential Tremor.
Int J Mol Sci
December 2024
Section of Neurology, Hospital Universitario del Sureste, 28500 Arganda del Rey, Spain.
Many clinical, neuroimaging, neuropathological, epidemiological, and genetic data suggest a relationship between essential tremor (ET) and Parkinson's disease (PD). Several hypothesis-based gene association studies attempted to find a genetic association between these diseases. Recent case-control association studies in Chinese and Spanish populations showed a marginal association between the rs1922452 and rs951818 single nucleotide variants (SNVs) and the risk of PD.
View Article and Find Full Text PDFEuropean consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2024.
Eur J Cancer
January 2025
University of Perugia, Unit of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
A unique collaboration of multi-disciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF), and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on cutaneous melanoma diagnosis and treatment, based on systematic literature reviews and the experts' experience. Cutaneous melanomas are excised with one to two-centimeter safety margins. For a correct stage classification and treatment decision, a sentinel lymph node biopsy shall be offered in patients with tumor thickness ≥ 1.
View Article and Find Full Text PDFFractional Dolphin Tenotomy for Boutonniere Deformity: A Cadaveric Study.
J Hand Surg Glob Online
November 2024
Department of Orthopaedics, The University of North Carolina School of Medicine, Chapel Hill, NC.
Purpose: Terminal extensor tenotomy or Dolphin tenotomy, is a described treatment for the management of distal interphalangeal (DIP) joint hyperextension in chronic boutonniere deformity. The purpose of this study was to investigate the effects of incremental partial Dolphin tenotomy in correcting boutonniere deformity, with a focus on evaluating the improvement in DIP joint hyperextension deformity and documenting the development of iatrogenic mallet finger.
Methods: Thirty-eight fingers from 10 cadaveric hands were used.
Performance of fine particulate matter data on air quality in an epidemiological study in Salvador, Brazil.
Rev Bras Epidemiol
December 2024
Fundação Oswaldo Cruz, Laboratory of Molecular Biology and Biostatistics - Salvador (BA), Brazil.
Objective: To evaluate the performance of satellite-derived PM2.5 concentrations against ground-based measurements in the municipality of Salvador (state of Bahia, Brazil) and the implications of these estimations for the associations of PM2.5 with daily non-accidental mortality.
View Article and Find Full Text PDFThe Relationship of Pitch Discrimination with Segregation of Tonal and Speech Streams for Cochlear Implant Users.
Trends Hear
December 2024
Auditory Research Center, Caruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Cochlear implant (CI) users often complain about music appreciation and speech recognition in background noise, which depend on segregating sound sources into perceptual streams. The present study examined relationships between frequency and fundamental frequency (F0) discrimination with stream segregation of tonal and speech streams for CI users and peers with no known hearing loss. Frequency and F0 discrimination were measured for 1,000 Hz pure tones and 110 Hz complex tones, respectively.
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