Objectives: To evaluate the effect of sub-growth-inhibitory concentrations of omadacycline on ATCC 10832 haemolytic activity .
Methods: Following determination of the MICs of omadacycline and comparator antibiotics, the strain was grown in the presence of individual antibiotics and the percentage of haemolysis assayed; 'washout' experiments were performed with omadacycline only.
Results: Omadacycline inhibited haemolytic activity at sub-growth-inhibitory concentrations. Inhibition was maintained at least 4 h after removal of extracellular drug.
Conclusions: Omadacycline's potency and suppression of virulence factors might contribute to its efficacy in the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia caused by virulent strains of . This finding could be relevant for other organisms and virulence factors that depend on new protein synthesis.
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| http://dx.doi.org/10.1093/jacamr/dlab190 | DOI Listing |
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