Collimator hole angulation was measured at 16 locations in three collimators used in SPECT. The parallel hole collimator measured -0.1 +/- -0.1 s.d. degrees in the X and -0.2 +/- 0.1 s.d. degrees in the Y direction. One 30 degree nominal slant hole collimator revealed a 0.1 +/- 0.3 s.d. degrees angulation in X and 26.5 +/- 1.1 s.d. degrees angulation in Y, which was unacceptable. The replacement collimator measured 0.0 +/- 0.1 s.d. degrees in X and 29.6 +/- 0.2 s.d. degrees in Y. Determination of collimator hole angulation is recommended as an acceptance test for SPECT systems. The net angle of tilt with respect to the orthogonal resulting from a particular collimator and camera head tilt was determined from summed projection images over 360 degrees of a point source placed off the axis of rotation. These measurements were sensitive within a 0.5 degree tilt angle. The method is suggested as a routine quality control procedure to optimize camera head tilt to a particular collimator. It may also reveal unexpected mechanical misalignments in the camera gantry.
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Neuro Oncol
January 2025
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Background: Central nervous system (CNS) tumors lead to cancer-related mortality in children. Genetic ancestry-associated cancer prevalence and outcomes have been studied, but is limited.
Methods: We performed genetic ancestry prediction in 1,452 pediatric patients with paired normal and tumor whole genome sequencing from the Open Pediatric Cancer (OpenPedCan) project to evaluate the influence of reported race and ethnicity and ancestry-based genetic superpopulations on tumor histology, molecular subtype, survival, and treatment.
Neuro Oncol
January 2025
Department of Neurosurgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg.
Background: Peripheral nerve sheath tumors (PNSTs) encompass entities with different cellular differentiation and degrees of malignancy. Spatial heterogeneity complicates diagnosis and grading of PNSTs in some cases. In malignant PNST (MPNST) for example, single cell sequencing data has shown dissimilar differentiation states of tumor cells.
View Article and Find Full Text PDFPhys Chem Chem Phys
January 2025
Department of Applied Physics, Hebrew University, Jerusalem, Israel.
In an era of interdisciplinary scientific research, new methodologies are necessary to simultaneously advance several fields of study. One such case involves the measurement of electron spin effects on biological systems. While magnetic effects are well known in biology, recent years have shown a surge in published evidence isolating the dependence on spin, rather than magnetic field, in biological contexts.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego.
Importance: The degree that in-home cannabis smoking can be detected in the urine of resident children is unclear.
Objective: Test association of in-home cannabis smoking with urinary cannabinoids in children living at home.
Design, Setting, And Participants: This cross-sectional study used baseline data from Project Fresh Air, a 2012-2016 randomized clinical trial to reduce fine particulate matter levels.
Dokl Biochem Biophys
January 2025
Kazan Institute of Biochemistry and Biophysics, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences,", 420111, Kazan, Russia.
Cytochromes of the P450 superfamily are widespread in nature; they were found in all studied aerobic organisms. Although the degree of similarity between cytochromes P450 of different families is low, all enzymes of this superfamily have similar tertiary structures. In addition, all cytochromes P450, including enzymes of the CYP74 clan, contain substrate recognition sites in their sequences, which form the catalytic center.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!