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| http://dx.doi.org/10.1073/pnas.2118943118 | DOI Listing |
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The utility of multiple assessments in infancy and toddlerhood to predict middle childhood ADHD symptoms: Temperamental, behavioral, and genetic contributions.
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Department of Psychology, Arizona State University, USA.
Background: Early intervention is effective for reducing ADHD symptoms and related impairments, yet methods of identifying young children in need of services are lacking. Most early predictors of ADHD previously identified are of limited clinical utility. This study examines several theoretically relevant predictors of ADHD in infancy and toddlerhood and whether assessment at multiple time points improves prediction.
View Article and Find Full Text PDFSmoothed Particle Hydrodynamics for free-surface and multiphase flows: a review.
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Istituto di Ingegneria del Mare Consiglio Nazionale delle Ricerche, Via di Vallerano 139, Roma, Lazio, 00128, ITALY.
The Smoothed Particle Hydrodynamics (SPH) method is expanding and applied to more and more fields, particularly in engineering. The majority of current SPH developments deal with free-surface and multiphase flows, especially for situations where geometrically complex interface configurations are involved. The present review article covers the last 25 years of development of the method to simulate such flows, discussing the related specific features of the method.
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PLoS One
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Unraveling the metabolism of Treponema pallidum is a key component to understanding the pathogenesis of the human disease that it causes, syphilis. For decades, it was assumed that glucose was the sole carbon/energy source for this parasitic spirochete. But the lack of citric-acid-cycle enzymes suggested that alternative sources could be utilized, especially in microaerophilic host environments where glycolysis should not be robust.
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Proc Natl Acad Sci U S A
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Class I major histocompatibility complex (MHC-I) proteins play a pivotal role in adaptive immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and TAPBPR promote the selection of immunogenic antigens from a large pool of intracellular peptides. Interactions of chaperoned MHC-I molecules with incoming peptides are transient in nature, and as a result, the precise antigen proofreading mechanism remains elusive.
View Article and Find Full Text PDFImmunohistochemical insights into hypothermia-related deaths: a systematic review.
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Department of Law, Institute of Legal Medicine, University of Macerata, Macerata, Italy.
Purpose: Hypothermia occurs when core body temperature drops below 35 °C. The purpose of this review was to identify and analyze studies on the topic of hypothermia from an immunohistochemical perspective to determine robust markers of fatal hypothermia.
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