In this issue, Bossart et al. report the in vivo receptor occupancy, body weight lowering effects in monkeys, and first-in-human results of SAR441255, a balanced GLP-1R/GIPR/GcgR triagonist. Following single doses to humans, SAR441255 shows positive acute glucoregulatory effects and an acceptable safety profile on gastrointestinal tolerability and cardiovascular hemodynamics.
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| http://dx.doi.org/10.1016/j.cmet.2021.12.010 | DOI Listing |
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