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Dopamine genetic risk scores and psychiatric symptoms: Interacting risk factors for impulse control behaviours in de novo Parkinson's disease.
J Neuropsychol
January 2025
Department of Health, Medical and Neuropsychology, Leiden University, Leiden, The Netherlands.
Up to 45% of patients with Parkinson's disease (PD) experience impulse control disorders (ICDs), characterized by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development of ICDs in PD. A total of 278 de novo PD patients (ICD-free at enrollment) were selected from the Parkinson's Progression Markers Initiative database.
View Article and Find Full Text PDFUBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer.
J Transl Med
January 2025
Department of Gynecology, The Fourth Hospital of Hebei Medical University, No.12 Jiankang Road, Shijiazhuang, 050000, Hebei, China.
Background: Immune cells within tumor tissues play important roles in remodeling the tumor microenvironment, thus affecting tumor progression and the therapeutic response. The current study was designed to identify key markers of plasma cells and explore their role in high-grade serous ovarian cancer (HGSOC).
Methods: We utilized single-cell sequencing data from the Gene Expression Omnibus (GEO) database to identify key immune cell types within HGSOC tissues and to extract related markers via the Seurat package.
Knowledge and attitude of nosocomial infection prevention and control precautions among healthcare personnel at Kiruddu Referral Hospital in Kampala, Uganda.
BMC Health Serv Res
January 2025
Department of Biological Sciences, Faculty of Science, Kyambogo University, Kampala, Uganda.
Background: A key concern for global public health is nosocomial infections. Essential to the fight against nosocomial infection, is healthcare professionals' knowledge and attitudes. Therefore, this study investigated healthcare professionals' knowledge and attitudes toward nosocomial infection at the Kiruddu Referral Hospital, Kampala, Uganda.
View Article and Find Full Text PDFExploring barriers to rehabilitation for individuals with spinal cord injury: a qualitative study in Iran.
BMC Health Serv Res
January 2025
Department of Social Welfare Management, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Objectives: Rehabilitation services are crucial for improving the quality of life and overall health of individuals with spinal cord injuries (SCIs). However, access to adequate rehabilitation remains limited in many regions, including Iran. This study aims to explore the barriers faced by individuals with SCIs in accessing appropriate rehabilitation services within Golestan province, northern of Iran.
View Article and Find Full Text PDFWork intensification and occupational fatigue on nurses: a cross-sectional and correlational study.
BMC Health Serv Res
January 2025
Department of Nursing Management, Florence Nightingale Faculty of Nursing, Istanbul University-Cerrahpaşa, Istanbul, Türkiye.
Purpose: This research aimed to determine the relationship between work intensification and occupational fatigue in nurses using a cross-sectional and correlational design.
Methods: The sample included 597 nurses from public, private, and university hospitals in Istanbul, selected through convenience sampling. Data were collected using the "Nurse Information Form," the "Intensification of Job Demands Scale," and the "Occupational Fatigue Exhaustion/Recovery Scale.
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