The biofilm formation is a dynamic process of bacterial growth,and the extracellular components can encase these microorganisms,making them more resistant to antibiotics and host immune attack.The formation of antibiotic-resistant bacterial biofilms will be a major challenge for the treatment and control of clinical infections. is a common clinical pathogen.Hypervirulent and carbapenem-resistant can cause serious infectious diseases,and the formation of its biofilm will aggravate this situation.In-depth research on the formation of biofilm and its regulatory mechanism can shed light on clinical anti-infection treatment and control.This article mainly reviews the latest research progress in the effects of fimbriae,polysaccharides,quorum sensing systems,and efflux pumps on the formation of biofilm and their regulatory mechanisms.
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