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In this review we have compiled multicomponent reactions (MCRs) that produce cyclic structures. We have covered articles reported since 2019 to showcase the recent advances in this area. In contrast to other available reviews on this topic, we focus specifically on MCRs with strong prospects in medicinal chemistry.
View Article and Find Full Text PDFInsights into the Role of the Glymphatic System in the Pathogenesis of Post-hemorrhagic Hydrocephalus.
Mol Neurobiol
January 2025
Department of Pediatric Surgery, Division of Neurosurgery, McGovern Medical School at UTHealth, Houston, TX, USA.
Recently, it has been well-established that the glymphatic or glial-lymphatic system plays a vital role in the pathophysiology of various neurological compromise, especially hydrocephalus (HCP). Till now, the complete pathway is not yet fully understood, and little evidence is available from the literature that links hydrocephalus to disorders of the glymphatic system. Most published molecular studies and animal research have shown that, in models with hydrocephalus, the drainage of cerebrospinal fluid (CSF) via the glymphatic system is disrupted.
View Article and Find Full Text PDFRecent Advances in the Genetics of Ataxias: An Update on Novel Autosomal Dominant Repeat Expansions.
Curr Neurol Neurosci Rep
January 2025
Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, QC, Canada.
Purpose Of Review: Autosomal dominant cerebellar ataxias, also known as spinocerebellar ataxias (SCAs), are genetically and clinically diverse neurodegenerative disorders characterized by progressive cerebellar dysfunction. Despite advances in sequencing technologies, a large proportion of patients with SCA still lack a definitive genetic diagnosis. The advent of advanced bioinformatic tools and emerging genomics technologies, such as long-read sequencing, offers an unparalleled opportunity to close the diagnostic gap for hereditary ataxias.
View Article and Find Full Text PDFInflammasome activation in melanoma progression: the latest update concerning pathological role and therapeutic value.
Arch Dermatol Res
January 2025
Uttaranchal Institute of Pharmaceutical Sciences, Division of research and innovation, Uttaranchal University, Dehradun, Uttarakhand, India.
The progression of melanoma is a complex process influenced by both internal and external cues which encourage the transition of tumour cells, uncontrolled growth, migration, and metastasis. Additionally, inflammation allows tumours to evade the immune system, contributing to cancer development. The inflammasome, a complex of many proteins, is crucial in enhancing immune responses to external and internal triggers.
View Article and Find Full Text PDFABCoRT: Retention Time Prediction for Metabolite Identification via Atom-Bond Co-Learning.
J Chem Inf Model
January 2025
School of Information Science and Engineering, Yunnan University, Kunming650091,China.
Liquid chromatography retention time (RT) prediction plays a crucial role in metabolite identification, a challenging and essential task in untargeted metabolomics. Accurate molecular representation is vital for reliable RT prediction. To address this, we propose a novel molecular representation learning framework, ABCoRT(tom-ond -learning for etention ime prediction), designed for predicting metabolite retention times.
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