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Vitrification and rapid rewarming of precision-cut liver slices for pharmacological and biomedical research.
bioRxiv
December 2024
Department of Mechanical Engineering, University of Minnesota, MN, USA.
Background And Aims: High-throughput in vitro pharmacological toxicity testing is essential for drug discovery. Precision-cut liver slices (PCLS) provide a robust system for screening that is more representative of the complex 3D structure of the whole liver than isolated hepatocytes. However, PCLS are not available as off-the-shelf products, significantly limiting their translational potential.
View Article and Find Full Text PDFThe Need for Early Engagement with Interested Groups on Advanced Biopreservation.
J Law Med Ethics
December 2024
UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MINNESOTA, USA.
Research on advanced biopreservation - technologies that include, for example, partial freezing, supercooling, and vitrification with nanoparticle infusion and laser rewarming - is proceeding at a rapid pace, potentially affecting many areas of medicine and the life sciences, food, agriculture, and environmental conservation. Given the breadth and depth of its medical, scientific, and corresponding social impacts, advanced biopreservation is poised to emerge as a disruptive technology with real benefits, but also ethical challenges and risks. Early engagement with potentially affected groups can help navigate possible societal barriers to adoption of this new technology and help ensure that emerging capabilities align with the needs, desires, and expectations of a broad range of interested parties.
View Article and Find Full Text PDFThe effect of rewarming ischemia on tissue transcriptome and metabolome signatures: A clinical observational study in lung transplantation.
J Heart Lung Transplant
October 2024
Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium; Department of Chronic Diseases and Metabolism, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium. Electronic address:
Background: In lung transplantation (LuTx), various ischemic phases exist, yet the rewarming ischemia time (RIT) during implantation has often been overlooked. During RIT, lungs are deflated and exposed to the body temperature in the recipient's chest cavity. Our prior clinical findings demonstrated that prolonged RIT increases the risk of primary graft dysfunction.
View Article and Find Full Text PDFCold Environment-Associated Extremity Lesions or Severe Hypothermia Help Differentiate Between Frostbitten and Trench Foot (Immersion Foot).
Int J Low Extrem Wounds
October 2024
Department of Plastic and Reconstructive Surgery, Aizawa Hospital, Matsumoto, Nagano, Japan.
Article Synopsis
- Cold foot injuries like frostbite and trench foot are common in very cold places.
- Frostbite is when the foot freezes, while trench foot happens when the foot gets too wet and cold, but doesn't freeze.
- It's important to tell them apart because treating them wrong can make things worse, and signs like frostbite on fingers can help doctors know which one it is.
Case Study of Severe Accidental Hypothermia with Rapid Cooling, Preserved Shivering, and Consciousness with a Summary of Similar Case Reports.
Wilderness Environ Med
December 2024
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, Canada.
Article Synopsis
- The case discusses a kayaker who experienced severe accidental hypothermia after a 50-minute immersion in 3°C water, managing to remain conscious and shivering despite a low core temperature of 22.9°C.
- Typically, severe hypothermia results in unconsciousness and the absence of shivering, but this patient’s experience challenges those expectations.
- The findings suggest that rapid, minimally invasive rewarming is possible even in severely hypothermic individuals who show signs of consciousness and shivering, emphasizing the need for a comprehensive assessment rather than strict adherence to hypothermia classification systems.
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