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| http://dx.doi.org/10.1016/j.xjtc.2021.09.012 | DOI Listing |
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Paralabral cysts in the acetabulum often occur in the setting of labral tears. While labral tears are commonly identified in femoroacetabular impingement syndrome, developmental dysplasia of the hip is also a cause of chondrolabral pathology. Our understanding of paralabral cysts has encouraged addressing the concomitant labral pathology, as this has been shown to result in cyst resolution.
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Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.
This commentary provides an in-depth analysis and perspective on the pioneering research article titled 'Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene Delivery to the Heart'. The original study explores the innovative use of extracellular vesicle-encapsulated AAVs (EV-AAV-6 and -9) as a superior gene-delivery approach for cardiomyocytes (CMs), which not only provides increased AAV neutralizing antibody (NAb) resistance but also has implications for increased gene delivery efficacy to ischemic hearts. This study examined the efficacy of EVs isolated from the conditioned medium of AAV-6 and -9 producing HEK293T cells in combinatorial and in systems in comparison to free AAVs in the presence of the NAbs.
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University of Portland, Portland, OR, USA.
Leadership positions with enormous responsibilities are challenging; at times leaders may feel isolated or lonely. A mastermind team is a small group of peer mentors or a personal board of directors, who meet on a recurring basis to share ideas for feedback, groupsource solutions, and to celebrate/commiserate on events. Joining a mastermind team helps leaders receive psychological support, encouragement, inspiration, suggestions for solving problems, and resources to manage challenges.
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View Article and Find Full Text PDF, , and identified as antibiotic-producers from freshwater.
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Beloit College, Beloit, Wisconsin, United States.
Three water isolates were previously identified as promising antibiotic producers from freshwater sources in Wisconsin, United States. Each isolate produced effective antibiotics against three or more bacterial relatives of antibiotic resistant pathogens. The isolates were identified as , , and through 16S rRNA sequencing and further characterized with biochemical tests to verify the genus and species of each isolate.
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