Background: Diabetes is one of the common chronic diseases in which susceptibility is determined by a combination of genetic and environmental factors, and more than 90% of diabetic patients are diabetes mellitus type 2 (T2DM). The existing studies on the association between CDKAL1 rs10946398 gene polymorphism and susceptibility to type 2 diabetes are inconsistent across populations.
Aim: We aim to explore the association between CDKAL1 rs10946398 gene polymorphism and susceptibility to type 2 diabetes in different populations.
Methods: We examined all studies before June 12, 2021, that associated CDKAL1 rs10946398 with T2DM. Heterogeneity was assessed by meta-analysis of allelic inheritance models (A vs. C), dominant inheritance models (AA vs. AC+CC), and recessive inheritance model (AA+AC vs. CC); was used to assess the heterogeneity (if < 50%, the fixed-effects model was used; if ≥ 50%, the random-effects model was used for data consolidation); correlation was judged by a forest map; potential publication bias was tested by the Egger test ( > 0.05 indicates that there is no publication bias).
Results: Fourteen data totaling 30288 subjects, including 19272 controls and 11016 patients with T2DM, met our inclusion criteria. In the Asian population, the differences were statistically significant ( < 0.01) for dominant genetic model (OR = 0.75, 95%CI = 0.64-0.88, = 0.0003). But the allelic effect model (OR = 0.87, 95%CI = 0.75-1.02, = 0.08) and the recessive genetic model (OR = 0.85, 95%CI = 0.66-1.10, = 0.23) were not statistically significant ( > 0.01). In the non-Asian population, the differences were statistically significant ( < 0.01) for the allelic effect model (OR = 0.83, 95%CI = 0.77-0.88, < 0.00001), the dominant model (OR = 0.79, 95%CI = 0.72-0.87, < 0.00001), and the recessive model (OR = 0.78, 95%CI = 0.70-0.87, < 0.0001).
Conclusion: In this study, CDKAL1 RS10946398 was positively associated with T2DM, but the association was different in Asian populations.
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| http://dx.doi.org/10.1155/2021/1254968 | DOI Listing |
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