Two new benzoic acids, cladoslide A () and cladoslide B (); one new β-carboline derivative, cladospomine (); and one new pyridin-2(1)-one, cladoslide C (), were isolated from the fermentation cultures of the mangrove-derived fungus sp. HNWSW-1, along with the previously reported -acetyl-β-oxotryptamine (), (4,5,11)--cladospolide B (), (4,5,11)--cladospolide B (), and (4,5,11)--cladospolide B (). Their structures were elucidated by spectroscopic analysis, Rh(OCOCF)-induced ECD experiments, and Marfey's method. Compound showed cytotoxicity against the K562 cell line with IC values of 13.10 ± 0.08 M. Moreover, compounds and exhibited inhibitory activity against α-glycosidase with IC values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.
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| http://dx.doi.org/10.3389/fchem.2021.773703 | DOI Listing |
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