Three new limonoids, walsurauias A-C (1-3), along with four known ones, were isolated from the leaves and twigs of Walsura yunnanensis C. Y. Wu. Their structures were determined on the basis of comprehensive spectroscopic data analysis. The new limonoids were screened for their cytotoxic activity (IC 0.81-5.73 μM) against four human cancer cell lines, including A549, HepG2, HCT116 p21KO and CNE-2. And α,β-unsaturated ketone moieties in rings A and B are essential for their cytotoxic activity. Selected compounds were further investigated. Compounds 1-3 effectively induced G2/M cell cycle arrest and apoptosis in a dose-dependent manner in cancer cells. In addition, compounds 1-3 inhibited the colony formation and compounds 2 and 3 suppressed the migration of cancer cells.
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Identification of limonoids from Walsura yunnanensis and evaluation of their cytotoxicity against cancer cell lines.
Fitoterapia
March 2022
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. Electronic address:
Three new limonoids, walsurauias A-C (1-3), along with four known ones, were isolated from the leaves and twigs of Walsura yunnanensis C. Y. Wu.
View Article and Find Full Text PDFLimonoids from the Leaves and Twigs of Walsura yunnanensis.
J Nat Prod
August 2014
Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun, Mengla, Yunnan 666303, People's Republic of China.
Nine new cedrelone limonoids, namely, walsuranolide B (1), 11β-hydroxy-23-O-methylwalsuranolide (2), yunnanolide A (3), yunnanol A (4), 11β-hydroxyisowalsuranolide (5), 11β-hydroxy-1,2-dihydroisowalsuranolide (6), 1α,11β-dihydroxy-1,2-dihydroisowalsuranolide (7), 11β-hydroxy-1α-methoxy-1,2-dihydroisowalsuranolide (8), and yunnanolide B (9), together with a new cycloartane triterpenoid, (24S*,25R*)-cycloartane-3β,24,25,26-tetrol (10), were isolated from the leaves and twigs of Walsura yunnanensis. Their structures were elucidated on the basis of spectroscopic analysis and by comparison with literature data. Compounds 3 and 5 exhibited potent cytotoxicity against five human tumor cell lines with IC50 values in the range 2.
View Article and Find Full Text PDFNew antioxidant phenolic glycosides from Walsura yunnanensis.
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State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Four new polyphenolic glycosides (1-4) were isolated from the BuOH extract of the bark of Walsura yunnanenis C. Y. Wu.
View Article and Find Full Text PDFTetranortriterpenoids from Walsura yunnanensis.
J Nat Prod
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Laboratory of Phytochemistry, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204 Yunnan, People's Republic of China.
Five new tetranortriterpenoids-walsurin (1), isowalsuranolide (2), walsuranolide (3), 11beta-acetoxywalsuranolide (4), and 20, 22-dihydro-22,23-epoxywalsuranolide (5)-and three new natural tetranortriterpenoids-11beta-hydroxydihydrocedrelone (6), 11beta-acetoxydihydrocedrelone (7), and 11beta-hydroxycedrelone (8)-together with a known tetranortriterpenoid, cedrelone (9), were isolated from the bark of Walsura yunnanensis. The structures of 1-8 were determined on the basis of spectral evidence.
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