AI Article Synopsis
- - The extrinsic pathway of apoptosis involves death receptors like CD95 and TRAILR-1/2, and problems with this process can lead to cancer and other issues.
- - c-FLIP is the main regulator in this pathway, playing a critical role in apoptosis while also influencing other cell death processes and cancer growth.
- - The text examines the structure, different forms, interactions, and modifications of c-FLIP, as well as potential strategies to target it for cancer treatment.
Article Abstract
The extrinsic pathway is mediated by death receptors (DRs), including CD95 (APO-1/Fas) or TRAILR-1/2. Defects in apoptosis regulation lead to cancer and other malignancies. The master regulator of the DR networks is the cellular FLICE inhibitory protein (c-FLIP). In addition to its key role in apoptosis, c-FLIP may exert other cellular functions, including control of necroptosis, pyroptosis, nuclear factor κB (NF-κB) activation, and tumorigenesis. To gain further insight into the molecular mechanisms of c-FLIP action in cancer networks, we focus on the structure, isoforms, interactions, and post-translational modifications of c-FLIP. We also discuss various avenues to target c-FLIP in cancer cells for therapeutic benefit.
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| http://dx.doi.org/10.1016/j.trecan.2021.12.002 | DOI Listing |
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