AI Article Synopsis
- Eremophila is a genus of desert plants from Australia used for traditional medicinal purposes by Aboriginal people.
- The leaf resin of Eremophila glabra has been found to inhibit certain enzymes important in glucose metabolism, with specific inhibitory concentrations measured.
- Seven new compounds, called eremoglabrane A-G, were isolated along with nine previously known compounds, with some of the new diterpenoids also exhibiting enzyme-inhibitory activity.
Article Abstract
Eremophila (Scrophulariaceae) is a genus of Australian desert plants, which have been used by Australian Aboriginal people for various medicinal purposes. Crude extracts of the leaf resin of Eremophila glabra (R.Br.) Ostenf. showed α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC values of 19.3 ± 1.2 μg/mL and 11.8 ± 2.1 μg/mL, respectively. Dual α-glucosidase/PTP1B high-resolution inhibition profiling combined with HPLC-PDA-HRMS and NMR were used to isolate and identify the compounds providing these activities. This resulted in isolation of seven undescribed serrulatane diterpenoids, eremoglabrane A-G, together with nine previously identified serrulatane diterpenoids and flavonoids. Three of the serrulatane diterpenoids showed PTP1B inhibitory activities with IC values from 63.8 ± 5.8 μM to 104.5 ± 25.9 μM.
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| http://dx.doi.org/10.1016/j.phytochem.2021.113072 | DOI Listing |
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