AI Article Synopsis
- Brown recluse spider bites can lead to serious health issues due to the release of toxic compounds that cause tissue damage and hemolysis.
- Diethyl azelate (DEA), a substance that helps improve cell membrane fluidity and has immune-boosting effects, was tested as a potential treatment for these bites.
- The study showed that topical application of DEA effectively healed spider bite wounds in humans within two weeks and inhibited harmful effects of the venom in laboratory settings, suggesting its promise as a treatment.
Article Abstract
Background/aim: Brown recluse spider bite releases hemolytic and cytotoxic phospholipase D to the wound that may cause necrosis or even death. We examined diethyl azelate (DEA), a plasma membrane fluidizer with a broad range of immunomodulatory activities, as a potential treatment for the brown recluse spider bite.
Materials And Methods: Topical DEA was used in emergency to treat brown recluse spider bites in a human subject. We subsequently evaluated the effects of DEA on hemolysis induced by the brown recluse spider venom, recluse recombinant phospholipase D (rPLD), and venoms from honey bee and moccasin snake, and on phospholipase A2 activity in the bee and snake venoms and in human urine.
Results: Topical DEA resolved the consequences of human brown recluse spider envenomation in two weeks. In vitro, DEA inhibited hemolysis caused by the brown recluse spider venom and rPLD and suppressed phospholipase A2 activity in a dose-dependent manner.
Conclusion: DEA is a promising novel therapy for the brown recluse spider bite and perhaps even unrelated envenomations involving PLDs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765177 | PMC |
| http://dx.doi.org/10.21873/invivo.12679 | DOI Listing |
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