We report the results from a new multicusp ion source (MIST-1) that produces record steady-state currents of H (1 mA) from this type of ion source with high purity (80% H ). We built MIST-1 to fulfill the stringent beam purity and beam quality requirements for IsoDAR, a proposed discovery-level neutrino experiment, requiring a 10 mA, 60 MeV/amu continuous wave (cw) proton beam on the target. IsoDAR will use a cyclotron accelerating H ions and using a novel radio frequency quadrupole (RFQ) direct injection method. Systematic measurements, varying discharge voltage, discharge current, and gas pressure, indicate that the ideal operating regime is at low pressure, high discharge current, and high discharge voltage. We have measured the combined species emittance after the source extraction to be <0.05 π-mm-mrad (rms, normalized) for a 0.95 mA beam. Beyond showing high currents and high H fraction, our measurements agree well with high fidelity simulations. These results show the feasibility of using a multicusp ion source for IsoDAR and the RFQ direct injection prototype and paves the way to record breaking cw beam currents of 5 mA H (equivalent to 10 mA protons) from compact cyclotrons, ideal for underground installation.
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http://dx.doi.org/10.1063/5.0063301 | DOI Listing |
Biochem Soc Trans
January 2025
Departamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud-sección Medicina, Universidad de La Laguna, Tenerife, ES-38071, Spain.
Large conductance voltage- and calcium-activated potassium channels (BK channels) are extensively found throughout the central nervous system and play a crucial role in various neuronal functions. These channels are activated by a combination of cell membrane depolarisation and an increase in intracellular calcium concentration, provided by calcium sources located close to BK. In 2001, Isaacson and Murphy first demonstrated the coupling of BK channels with N-methyl-D-aspartate receptors (NMDAR) in olfactory bulb neurons.
View Article and Find Full Text PDFRSC Adv
January 2025
Department of Food Technology, College of Agriculture Engineering Sciences, Salahaddin University-Erbil Erbil Kurdistan Region Iraq
Arsenic (As) contamination in groundwater has become a global concern, and it poses a serious threat to the health of millions of people. Groundwater with high As concentrations has been reported worldwide. It is widely recognized that the toxicity of As largely depends on its chemical forms, making As speciation a critical issue.
View Article and Find Full Text PDFPharm Nanotechnol
January 2025
Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York, United States of America.
Metallic nanostructures play a vital role in technological advancement, providing exceptional performance and improved adaptability in comparison to their bulk equivalents. Conventional synthesis techniques frequently depend on dangerous reducing agents to transform metal ions into Nanoparticles (NPs), which presents considerable environmental and health issues. In contrast, the approach of green synthesis, which emphasizes the use of non-toxic reagents, has garnered significant interest as a sustainable method for the fabrication of Metallic Nanoparticles (MNPs).
View Article and Find Full Text PDFMass Spectrom Rev
January 2025
School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in-source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources.
View Article and Find Full Text PDFEnviron Sci Technol
January 2025
Department of Environmental Science, Stockholm University, Stockholm 10691, Sweden.
The complex and dynamic nature of airborne fine particulate matter (PM) has hindered understanding of its chemical composition, sources, and toxic effects. In the first steps of a larger study, here, we aimed to elucidate relationships between source regions, ambient conditions, and the chemical composition in water extracts of PM samples ( = 85) collected over 16 months at an observatory in the Yellow Sea. In each extract, we quantified elements and major ions and profiled the complex mixtures of organic compounds by nontarget mass spectrometry.
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