AI Article Synopsis
- Human iPSC cell line FAMRCi009-A was created from a patient with restrictive cardiomyopathy and a specific genetic variant (FLNC p.Val2264Met).
- The cell line was generated using non-integrative Sendai viruses, resulting in iPSCs that have a normal karyotype and express key pluripotency markers.
- These iPSCs demonstrated the ability to differentiate into three germ layers in vitro, making them valuable for studying filaminopathies in greater detail.
Article Abstract
Human iPSC cell line FAMRCi009-A was generated from a patient with restrictive cardiomyopathy and congenital myopathy carrying FLNC p.Val2264Met genetic variant. Patient-specific peripheral blood mononuclear cells were reprogrammed using non-integrative Sendai viruses. Generated iPSC lines showed normal karyotype, expressed pluripotency markers and exhibited trilineage differentiation potential in vitro. The reported iPSC lines could be used for a deeper study of filaminopathies.
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| http://dx.doi.org/10.1016/j.scr.2021.102640 | DOI Listing |
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