AI Article Synopsis
- The study focuses on creating a new rapid imaging technique using hyperpolarized carbon MRI to capture real-time metabolic reactions in small areas of the body during medical imaging.
- A specialized pulse sequence was developed, tested in laboratory settings, and later applied to live rats to track metabolic changes related to two carbon compounds, achieving impressive spatial and temporal resolution.
- Results showed that this new imaging strategy effectively differentiated metabolic activity across organs, with certain metabolic processes, like the conversion of pyruvate to lactate, prominent in the liver and others in the kidneys and heart, enabling better understanding of metabolic pathways.
Article Abstract
Purpose: Hyperpolarized (HP) C MRI has enabled real-time imaging of specific enzyme-catalyzed metabolic reactions, but advanced pulse sequences are necessary to capture the dynamic, localized metabolic information. Herein we describe the design, implementation, and testing of a rapid and efficient HP C pulse sequence strategy on a cryogen-free simultaneous positron emission tomography/MR molecular imaging platform with compact footprint.
Methods: We developed an echo planar spectroscopic imaging pulse sequence incorporating multi-band spectral-spatial radiofrequency (SSRF) pulses for spatially coregistered excitation of C metabolites with differential individual flip angles. Excitation profiles were measured in phantoms, and the SSRF-echo planar spectroscopic imaging sequence was tested in rats in vivo and compared to conventional echo planar spectroscopic imaging. The new sequence was applied for 2D dynamic metabolic imaging of HP [1- C]pyruvate and its molecular analog [1- C] -ketobutyrate at a spatial resolution of 5 mm × 5 mm × 20 mm and temporal resolution of 4 s. We also obtained simultaneous F-fluorodeoxyglucose positron emission tomography data for comparison with HP [1- C]pyruvate data acquired during the same scan session.
Results: Measured SSRF excitation profiles corresponded well to Bloch simulations. Multi-band SSRF excitation facilitated efficient sampling of the multi-spectral kinetics of [1- C]pyruvate and [1- C] - . Whereas high pyruvate to lactate conversion was observed in liver, corresponding reduction of -ketobutyrate to [1- C] -hydroxybutyrate ( HB) was largely restricted to the kidneys and heart, consistent with the known expression pattern of lactate dehydrogenase B.
Conclusion: Advanced C SSRF imaging approaches are feasible on our compact positron emission tomography/MR platform, maximizing the potential of HP C technology and facilitating direct comparison with positron emission tomography.
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| http://dx.doi.org/10.1002/mrm.29145 | DOI Listing |
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