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The ileocecal valve in transabdominal ultrasound. Part 2: Pathological lesions.
J Ultrason
December 2024
Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University, Szczecin, Poland.
The aim of this paper is to present our experience in transabdominal ultrasonography of ileocecal valve lesions. The ileocecal valve, located in the central part of the ileocecal bowel segment, is rarely the primary site of disease processes. It is usually involved by pathologies in adjacent bowel segments.
View Article and Find Full Text PDFDexmedetomidine Regulates Macrophage Phenotype Remodeling Through AMPK/SIRT1 to Alleviate Inflammatory Mediators and Lung Injury.
J Biochem Mol Toxicol
January 2025
Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality in the intensive care unit (ICU) and can cause excessive inflammation. Dexmedetomidine (DEX) is a drug that exerts anti-inflammatory effects. Identifying the anti-inflammatory mechanism of DEX in the context of ALI/ARDS possesses potential significance for the prevention and treatment of ARDS.
View Article and Find Full Text PDFThe genomic and clinical consequences of replacing procarbazine with dacarbazine in escalated BEACOPP for Hodgkin lymphoma: a retrospective, observational study.
Lancet Oncol
December 2024
Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Faculty of Health, Medicine, and Social Care, Anglia Ruskin University, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK. Electronic address:
Background: Procarbazine-containing chemotherapy regimens are associated with cytopenias and infertility, suggesting stem-cell toxicity. When treating Hodgkin lymphoma, procarbazine in escalated-dose bleomycin-etoposide-doxorubicin-cyclophosphamide-vincristine-procarbazine-prednisolone (eBEACOPP) is increasingly replaced with dacarbazine (eBEACOPDac) to reduce toxicity. We aimed to investigate the impact of this drug substitution on the mutation burden in stem cells, patient survival, and toxicity.
View Article and Find Full Text PDFAcute Large Bowel Obstruction Post Umbilical Hernia Repair Surgery: A Case Report.
Cureus
October 2024
Surgery, Bakersfield Memorial, Bakersfield, USA.
Article Synopsis
- - Large bowel obstruction (LBO) is relatively rare, often caused by colorectal adenocarcinoma, and it typically presents with symptoms like abdominal pain, constipation, and nausea; a CT scan is crucial for diagnosis.
- - A case study of a 41-year-old male showed severe LBO after a hernia repair, requiring emergency surgery due to findings of a blocked sigmoid colon and complications like pneumatosis.
- - Diverticulitis, which is increasingly affecting younger individuals, can lead to bowel obstructions and serious complications; educating all patients about risk factors, including diet and surgical history, is important.
High-Grade B-Cell Lymphoma: An Atypical Mass in the Colon.
Mil Med
November 2024
Department of Gastroenterology, Naval Medical Center Portsmouth, Portsmouth, VA 23708, USA.
Masses in the colon can range from benign to malignant etiologies, with adenocarcinoma being the most common malignancy. Although the most frequently encountered hematologic malignancy in the military population, lymphoma is uncommonly identified during colonoscopy. We present a rare case of an active duty service member with abdominal pain and a large mesenteric mass with extension into the cecum that was a high-grade B-cell lymphoma diagnosed through endoscopy.
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