This study aimed to investigate effects of the selected prebiotics alone, and in combination with two potential probiotic strains on the microbial composition of gut microbiota and acid production. Four prebiotics, inulin, fructo-oligosaccharides, xylo-oligosaccharides, and isomalto-oligosaccharides were chosen, and glucose served as the carbon source. Supplementation of this four prebiotics increased numbers of and lactic acid bacteria while decreasing the pH value of fermentation broth inoculated with gut microbiota compared to glucose. Then, two potential probiotics derived from gut at different dosages, KM7 and LP4 were added with isomalto-oligosaccharides in fermentation broth inoculated with gut microbiota, respectively. The most pronounced impact was observed with isomalto-oligosaccharides. Compared to isomalto-oligosaccharides alone, the combination of isomalto-oligosaccharides with both lactobacilli strains induced the growth of , LAB, and total bacteria and reduced the proliferation of and fungi. Consistent with these results, the altered metabolic activity was observed as lowered pH in culture of gut microbiota supplemented with isomalto-oligosaccharides and lactobacilli strains. The symbiotic impact varied with the types and concentration of strains and fermentation time. The more effective ability was observed with IMO combined with KM7. These results suggested that isomalto-oligosaccharides could be a potential prebiotic and symbiotic with certain lactobacilli strains on gut microbiota.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702607 | PMC |
| http://dx.doi.org/10.33073/pjm-2021-049 | DOI Listing |
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