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| http://dx.doi.org/10.1186/s11658-021-00303-7 | DOI Listing |
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Molecular Oncology Laboratories, Department of Medical Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.
Exploring the neuroprotective potential of immunosuppressants in Parkinson's disease.
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Department of Neurology, Washington University School of Medicine in St. Louis, 660 S Euclid Ave, St. Louis, MO, 63110, USA. Electronic address:
Introduction: Neuroprotective therapy to slow Parkinson's disease (PD) progression is a critical unmet need. Neuroinflammation likely represents an important pathophysiologic mechanism for disease progression. Medications that target this inflammation, such as immunosuppressants, represent potential disease-modifying therapies for PD.
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Extended performance of cognitively demanding tasks induces cognitive fatigue manifested with an overall deterioration of behavioral performance. In particular, long practice with tasks requiring impulse control is typically followed by a decrease in self-control efficiency, leading to performance instability. Here, we show that this is due to changes in activation modalities of key task-related areas occurring if these areas previously underwent intensive use.
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J Neural Eng
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Department of Information Engineering, Electronics and Telecommunications, University of Rome La Sapienza, Piazzale Aldo Moro 5, Rome, 00185, ITALY.
Deep learning tools applied to high-resolution neurophysiological data have significantly progressed, offering enhanced decoding, real-time processing, and readability for practical applications. However, the design of artificial neural networks to analyze neural activity in vivo remains a challenge, requiring a delicate balance between efficiency in low-data regimes and the interpretability of the results. Approach: To address this challenge, we introduce a novel specialized transformer architecture to analyze single-neuron spiking activity.
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Scotland's Rural College Animal and Veterinary Sciences Research Group, Edinburgh, United Kingdom.
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