First report of steroid derivatives isolated from starfish with anti-bacterial, anti-cancer and anti-diabetic activities.

Chemical studies on have afforded two steroids, 5α-cholesta-24-en-3β,20β-diol-23-one () and 5α-cholesta-9(11)-en-3β, 20β-diol (). Structures compounds and were determined with the help of spectroscopic studies. Compound showed strong antibacterial activity (21.0 ± 0.06 mm) against . Compounds and were also active against human breast carcinoma cells (MCF-7) with LC values of 49 ± 1.6 and 57.5 ± 1.5 μg/ml, respectively. This bioactivity was comparable to the currently used anticancer agent, cisplatin (LC 46 ± 1.1 µg/ml). Compounds and exhibited anti-α-glucosidase activity with IC values of 58 ± 0.8 and 55 ± 0.5 µg/ml, respectively, whereas IC of Acarbose as a positive control was found to be 36 ± 0.4 µg/ml in our bioassay.