AI Article Synopsis
- Breast cancer is a leading cause of cancer-related deaths globally, with existing therapies needing improvement due to the presence of immunosuppressive cells that hinder effective treatment.
- The advent of immunotherapy offers potential advancements in breast cancer management, especially through combinatorial therapies that involve immune checkpoint blockade and targeting epigenetic regulators.
- The review highlights ongoing clinical trials assessing the use of epi-drugs in conjunction with immunotherapy for breast cancer, focusing on their effects within the tumor microenvironment and findings from recent research.
Article Abstract
Breast cancer is one of the leading causes of death among cancer patients worldwide. To date, there are several drugs that have been developed for breast cancer therapy. In the 21st century, immunotherapy is considered a pioneering method for improving the management of malignancies; however, breast cancer is an exception. According to the immunoediting model, many immunosuppressive cells contribute to immunological quiescence. Therefore, there is an urgent need to enhance the therapeutic efficacy of breast cancer treatments. In the last few years, numerous combinatorial therapies involving immune checkpoint blockade have been demonstrated that effectively improve clinical outcomes in breast cancer and combining these with methods of targeting epigenetic regulators is also an innovative strategy. Nevertheless, few studies have discussed the benefits of epi-drugs in non-cancerous cells. In this review, we give a brief overview of ongoing clinical trials involving combinatorial immunotherapy with epi-drugs in breast cancer and discuss the role of epi-drugs in the tumor microenvironment, including the results of recent research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594694 | PMC |
| http://dx.doi.org/10.3390/epigenomes4040027 | DOI Listing |
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