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Tetrahydropalmatine promotes macrophage autophagy by inhibiting the AMPK/mTOR pathway to attenuate atherosclerosis.
Histol Histopathol
September 2024
Traditional Chinese Medicine Dispensary, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Background: Atherosclerosis (AS) is a chronic progressive arterial disease that is associated with macrophage autophagy and AMP-activated protein kinase (AMPK)/mechanistic target of the rapamycin (mTOR) pathway. Tetrahydropalmatine (THP) can activate AMPK-dependent autophagy. We aim to study the mechanism of macrophage autophagy mediated by THP in the treatment of AS via the AMPK/mTOR pathway.
View Article and Find Full Text PDFEffects and mechanism of Kedaling tablets for atherosclerosis treatment based on network pharmacology, molecular docking and experimental study.
J Ethnopharmacol
January 2024
Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, 100091, China. Electronic address:
Ethnopharmacological Relevance: Kedaling tablets (KDL) are a Chinese patented medicine derived from Corydalis yanhusuo (Y.H. Chou & Chun C.
View Article and Find Full Text PDFFerulic acid, ligustrazine, and tetrahydropalmatine display the anti-proliferative effect in endometriosis through regulating Notch pathway.
Life Sci
September 2023
College of Pharmaceutical Sciences & Chinese Medicine, Southwest University, Chongqing, China; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Chongqing, China; Engineering Research Center of Coptis Development and Utilization, Ministry of Education, College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, China; National Demonstration Center for Experimental Pharmacy Education, Southwest University, Chongqing, China. Electronic address:
Aims: With an ambiguous anti-proliferative mechanism, the combination of ferulic acid, ligustrazine, and tetrahydropalmatine (FLT) shows good anti-endometriosis (EMS) activity. In EMS, the expression of Notch pathway and its role in proliferation are not yet unclear. In this study, we sought to uncover the role of Notch pathway's effect and FLT's anti-proliferative mechanism on EMS proliferation.
View Article and Find Full Text PDFMorphine Withdrawal-Induced Hyperalgesia in Models of Acute and Extended Withdrawal Is Attenuated by -Tetrahydropalmatine.
Int J Mol Sci
May 2023
Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2A1, Canada.
Effective pain control is an underappreciated aspect of managing opioid withdrawal, and its absence presents a significant barrier to successful opioid detoxification. Accordingly, there is an urgent need for effective non-opioid treatments to facilitate opioid detoxification. -Tetrahydropalmatine (-THP) possesses powerful analgesic properties and is an active ingredient in botanical formulations used in Vietnam for the treatment of opioid withdrawal syndrome.
View Article and Find Full Text PDF[Levo-tetrahydropalmatine promotes apoptosis of human hepatocellular carcinoma through switching energy metabolism phenotype via upregulation of mitochondrial reactive oxygen species].
Zhongguo Zhong Yao Za Zhi
December 2022
Department of Chemistry and Physics, State University of New York at Stony Brook Stony Brook, New York 11790-3400, USA.
Mitochondrion is an important organelle that maintains cellular homeostasis and plays a crucial role in determining cell fate. The present study investigated the effect of levo-tetrahydropalmatine(THP) on autophagic flux and energy metabolism phenotype of human hepatocellular carcinoma(HCC) SMMC-7721 and BEL-7402 cells. SMMC-7721 and BEL-7402 cells were treated with THP(100 μmol·L~(-1)) with or without N-acetyl-L-cysteine(NAC, 10 μmol·L~(-1)) for 24 h.
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